![]() Genetics and Rare Diseases Information Center. Hindawi: International Journal of Rheumatology. Clinical and immunological profile of mixed connective tissue disease and a comparison of four diagnostic criteria. Clinical manifestations of mixed connective tissue disease. If you have trigeminal neuralgia, even mild stimulation of your face - such as from brushing your teeth or putting on makeup - can trigger a jolt of severe pain. Sjogren syndrome can affect the nerve that carries feeling from your face to your brain (trigeminal nerve). More research is needed to understand this association. In one small study, hearing loss was reported in almost half the patients with mixed connective tissue disease. People with severe Raynaud's disease can develop gangrene in the fingers. ![]() About 75% of people with mixed connective tissue disease have iron deficiency anemia. You might have abdominal pain and problems with swallowing and digesting food. Commonly, mixed connective tissue disease affects the digestive tract. About one-fourth of people with mixed connective tissue disease develop kidney problems, Kidney involvement is usually mild, but can lead to kidney failure. Parts of the heart can enlarge, or inflammation can occur around the heart. This large group of disorders can cause scarring in your lungs, which affects your ability to breathe. This condition is a major cause of death in people with mixed connective tissue disease. High blood pressure in the lungs (pulmonary hypertension).Mixed connective tissue disease can lead to serious complications, some of which can be fatal. However, it appears to be most common in women under the age of 50. Mixed connective tissue disease can occur in people of any age. The use of scleroderma autoantibodies may be very helpful in determining the prognosis, as well as monitoring and treatment of scleroderma patients. But the role of genetics in the disease remains unclear. The many faces of scleroderma Scleroderma autoantibodies are associated with very specific demographic, clinical, organ system, and survival features. Some people with mixed connective tissue disease have a family history of the condition. In connective tissue diseases, your immune system attacks the fibers that provide the framework and support for your body. In autoimmune disorders, your immune system - responsible for fighting off disease - mistakenly attacks healthy cells. Mixed connective tissue disease is an autoimmune disorder, although the cause isn't known.
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